崔浩

发布者:李素珍发布时间:2022-11-21浏览次数:1185

崔浩


博士,副教授硕士生导师

 ● 学习、工作经历

2015/04-至今,江西师范大学

2013/04 - 2015/01IMBIMBMCUppsala University,瑞典,博士后

2009/07 - 2012/12Menzies Institute for Medical Research/University of Tasmania,澳大利亚,博士

2008/01 - 2009/06University of Tasmania,澳大利亚,硕士

2003/09 - 2007/07,南京中医药大学,学士

 ●研究兴趣、领域:

主要研究蛋白聚糖在生理(如发育)和病理(如阿尔茨海默症,肿瘤以及炎症等)过程中的功能及分子机制。同时进行天然多糖的结构分析、生物活性筛选和机制研究。

 ●开设的课程:

《分子生物学》(本科)、《分子生物学实验》(本科)、《糖生物学》(研究生)、《专业英语》(研究生)

 ●代表性论文:

1. Cui H, Wang ZG, Zhang TJ, Li JP, Fang JP*. (2021). Re-expression of glucuronyl C5-epimerase in the mutant MEF cells increases heparan sulfate epimerization but has no influence on the Golgi localization and enzymatic activity of 2-O-sulfotransferase. Glycobiology. 31(8): 1018-1025.

2. Cui H, Zhu XY, Wang ZG, Fang JP, Yuan T*. (2021). A Purified glucomannan oligosaccharide from Amorphophallus konjac improves colonic mucosal barrier function via enhancing butyrate production and histone protein H3 and H4 acetylation. Journal of Natural Products. 84(2): 427-435.

3. Cui H, Cheng X, Batool T, Zhang X, Li JP*. (2021). Glucuronyl C5-epimerase is crucial for epithelial cell maturation during embryonic lung development. Glycobiology. 31(3): 223-230.

4. Cui H, Zhu XY, Huo ZY, Liao BB, Huang JP, Wang ZG, Song CH, Hu XG, Fang JP*. (2020). A beta-glucan from Grifola frondosa effectively delivers therapeutic oligonucleotide into cells via dectin-1 receptor and attenuates TNFalpha gene expression. International Journal of Biological Macromolecules. 149: 801-808.

5. Tan YX *, Cui H *, Wan LM*, Gong F, Zhang X, Vlodavsky I, Li JP (2018). Overexpression of heparanase in mice promoted megakaryocytopoiesis. Glycobiology. Glycobiology. 28(5): 269-275.

6.Cui H, King AE, Jacobson GA, Small DH(2016). Peripheral treatment with enoxaparin exacerbates amyloid plaque pathology in Tg2576 mice. Journal Neuroscience Research. 95(4): 992-999.

7.Jendresen CB*, Cui H*, Zhang X, Vlodavsky I, Nilsson LN, Li JP (2015). Overexpression of heparanase lowers the amyloid burden in amyloid-beta precursor protein transgenic mice. The Journal of biological chemistry. 290(8): 5053-5064.

9. Cui H, Freeman C, Jacobson GA, Small DH (2013) Proteoglycans in the central nervous system: role in development, neural repair, and Alzheimer's disease, IUBMB life. 65(2): 108-120.

10. Cui H, Hung AC, Freeman C, Narkowicz C, Jacobson GA, Small DH (2012) Size and sulfation are critical for the effect of heparin on APP processing and A production, Journal of neurochemistry. 123(3): 447-457.

11. Cui H, Hung AC, Klaver DW, Suzuki T, Freeman C, Narkowicz C, Jacobson GA, Small DH (2011) Effects of heparin and enoxaparin on APP processing and Abeta production in primary cortical neurons from Tg2576 mice. PLoS One. 6(7): e23007.

* 共同第一作者

 ● 科研项目

1. 国家自然科学基金: 硫酸乙酰肝素差向异构化修饰对非小细胞肺癌中HGF/c-Met信号通路的调控作用与机制研究,批准号:32160222

2. 国家自然科学基金(青年): 硫酸乙酰肝素调控-分泌酶表达的作用机制研究,批准号:31700710

3. 江西师范大学青年英才资助培育计划,2017-2019

 ●联系方式:

地址:江西师范大学(瑶湖校区)方荫楼3W345

电话:13699553810

E-mailcuihaoeric@jxnu.edu.cn;cuihaoeric@163.com